abstract：BACKGROUND:Findings suggest approximately one in six people with intellectual disability engage in 'challenging behaviours', which include aggression towards others/property and self-injurious actions. In residential settings, actions of staff members can make challenging behaviours more likely to occur, or make these ...

journal_title：Trials

authors： Randell E,Hastings RP,McNamara R,Knight R,Gillespie D,Taylor Z

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:Current management for men with lower urinary tract symptoms (LUTS) is a pathway that results in prostate surgery in a significant proportion. While helpful in relieving benign prostatic obstruction (BPO), surgery may be ineffective for men suffering from difficulties not relating to BPO. The UPSTREAM trial ...

journal_title：Trials

authors： Young GJ,Lewis AL,Lane JA,Winton HL,Drake MJ,Blair PS

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:There are a large number of clinical outcome measures used to assess the effectiveness of prevention and management strategies of periodontal diseases. This heterogeneity causes difficulties when trying to synthesise data for systematic reviews or clinical guidelines, reducing their impact. Core outcome sets...

journal_title：Trials

authors： Lamont TJ,Clarkson JE,Ricketts DNJ,Heasman PA,Ramsay CR

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:As the toxicity associated with the α-GalCer-pulsed dendritic cell (DC) therapy could be considered to be negligible, its addition to postoperative adjuvant chemotherapy would be expected to greatly improve the therapeutic effect, and could result in prolonged survival. The aim of the present study is to com...

journal_title：Trials

authors： Saka H,Kitagawa C,Ichinose Y,Takenoyama M,Ibata H,Kato T,Takami K,Yamashita M,Maeda T,Takeo S,Ueda H,Okabayashi K,Nagashima S,Oka T,Kouso H,Fukuyama S,Yoshimoto K,Shimokawa M,Saito AM,Ito S

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is associated with reduced skin microbial diversity and overgrowth of Staphylococcus (S.) aureus. However, the importance of S. aureus colonisation in the complex pathogenesis remains unclear and studies on the effect of anti-staphylococcal therapy in non-infected AD show contradictory...

journal_title：Trials

authors： Totté J,de Wit J,Pardo L,Schuren F,van Doorn M,Pasmans S

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Adverse effects such as fatigue, pain, erythema, nausea and vomiting are commonly known in patients undergoing irradiation (RT) alone or in combination with chemotherapy (RCHT). Patients suffering from these symptoms are limited in their daily life and their quality of life (QOL) is often reduced. As address...

journal_title：Trials

authors： Asadpour R,Kessel KA,Bruckner T,Sertel S,Combs SE

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Orthodontic treatment is commonly undertaken in young people, with over 40% of children in the UK needing treatment and currently one third having treatment, at a cost to the National Health Service in England and Wales of £273 million each year. Most current research about orthodontic care does not consider...

journal_title：Trials

authors： Tsichlaki A,O'Brien K,Johal A,Marshman Z,Benson P,Colonio Salazar FB,Fleming PS

更新日期：2017-08-04 00:00:00

abstract：BACKGROUND:Studies exploring parents' trial experiences generally relate to their understanding of the consent process and the development of researcher strategies to facilitate recruitment and retention. The aim was to better understand parents' experience of being part of a trial at the time and their perceptions of ...

journal_title：Trials

authors： Harvey M,Nongena P,Edwards D,Redshaw M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Although conventional laparoscopic and hand-assisted laparoscopic surgery for colorectal cancer is widely used today, there remain many technical challenges especially for right colon cancer in obese patients. Herein, we develop a novel hand-assisted laparoscopic surgery (HALS) with complete mesocolic excisi...

journal_title：Trials

authors： Yang X,Wu Q,Jin C,He W,Wang M,Yang T,Wei M,Deng X,Meng W,Wang Z

更新日期：2017-07-26 00:00:00

abstract：BACKGROUND:People with decompensated cirrhosis require complex medical care and are often prescribed an intricate and frequently changing medication and lifestyle regimen. However, many patients mismanage their medications or have poor comprehension of their disease and self-management tasks. This can lead to harm, hos...

journal_title：Trials

authors： Hayward KL,Martin JH,Cottrell WN,Karmakar A,Horsfall LU,Patel PJ,Smith DD,Irvine KM,Powell EE,Valery PC

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:Lack of trust in parental support is a transdiagnostic risk factor for the development of psychological problems throughout the lifespan. Research suggests that children's cognitive attachment representations and related information processing biases could be an important target for interventions aiming to b...

journal_title：Trials

authors： Verhees MWFT,Ceulemans E,Bakermans-Kranenburg MJ,van IJzendoorn MH,de Winter S,Bosmans G

更新日期：2017-07-14 00:00:00

abstract：:There is a critical need for objective data to guide effective health promotion and care for homeless populations. However, many investigators exclude homeless populations from clinical trials due to practical concerns about conducting research with this population. This report is based on our experience and lessons l...

journal_title：Trials

authors： Ojo-Fati O,Joseph AM,Ig-Izevbekhai J,Thomas JL,Everson-Rose SA,Pratt R,Raymond N,Cooney NL,Luo X,Okuyemi KS

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:In recent years, cold hypersensitivity in the hands (CHH) has become a common ailment of women in Korea. It can lead to gynecological problems such as irregular menstruation, miscarriage, and infertility. Traditionally, Korean herbal medicine has been the primary treatment method used to balance thermoregula...

journal_title：Trials

authors： Ko Y,Go HY,Cho YY,Shin JH,Kim TH,Choi DJ,Lee JM,Jang JB,Song YK,Ko SG,Sun SH,Jeon CY

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:We sought to test the effectiveness of methadone and buprenorphine in the treatment of methamphetamine withdrawal craving over a 17-day treatment period. METHODS:Patients were randomized into one of two groups. The study sample comprised 40 male subjects dependent on methamphetamine who met criteria of the ...

journal_title：Trials

authors： Ahmadi J,Razeghian Jahromi L

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Multiple pregnancies are one of the major safety concerns of in vitro fertilization (IVF) due to the increased risk of maternal and neonatal complications. Single embryo transfer is the most effective way to reduce the risk of multiple pregnancies. Selection of the embryo and optimization of the implantation...

journal_title：Trials

authors： Wei D,Sun Y,Liu J,Liang X,Zhu Y,Shi Y,Chen ZJ

更新日期：2017-06-05 00:00:00

abstract：:In October 2015 we published the paper 'Measurement of HbA1c in multicentre diabetes trials - should blood samples be tested locally or sent to a central laboratory: an agreement analysis'. Chatterjee and Pradhan have submitted a letter to the editor asking critical questions regarding the methods we used. We offer th...

journal_title：Trials

authors： Arch BN,Blair J,McKay A,Gregory JW,Newland P,Gamble C

更新日期：2017-05-26 00:00:00

abstract：BACKGROUND:Pruritus (itch) is a frequent, burdensome and difficult-to-treat symptom in patients with cholestasis. Fibrates are currently under investigation for the treatment of primary biliary cholangitis in patients with a suboptimal response to ursodeoxycholic acid. Moreover, there is empirical evidence for a possib...

journal_title：Trials

authors： Bolier R,de Vries ES,Parés A,Helder J,Kemper EM,Zwinderman K,Elferink RPO,Beuers U,Netherlands Association for the Study of the Liver (NASL) Cholestatic Liver Diseases Study Group.

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Extended brief interventions (EBIs) are effective in targeting alcohol misuse in the general population. However, little is known of the effects of EBI in adults with intellectual (also known as learning) disabilities. In this feasibility trial we compared EBI with usual care for alcohol misuse in adults wit...

journal_title：Trials

authors： Kouimtsidis C,Bosco A,Scior K,Baio G,Hunter R,Pezzoni V,Mcnamara E,Hassiotis A

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS:Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, a...

journal_title：Trials

authors： Hind D,Reeves BC,Bathers S,Bray C,Corkhill A,Hayward C,Harper L,Napp V,Norrie J,Speed C,Tremain L,Keat N,Bradburn M

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on...

journal_title：Trials

authors： Bluth T,Teichmann R,Kiss T,Bobek I,Canet J,Cinnella G,De Baerdemaeker L,Gregoretti C,Hedenstierna G,Hemmes SN,Hiesmayr M,Hollmann MW,Jaber S,Laffey JG,Licker MJ,Markstaller K,Matot I,Müller G,Mills GH,Mulier JP,Pu

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:Transurethral resection of the prostate (TURP) has been the standard operation for benign prostatic obstruction (BPO) for 40 years, with approximately 25,000 procedures performed annually, and has remained largely unchanged. It is generally a successful operation, but has well-documented risks for the patien...

journal_title：Trials

authors： Worthington J,Taylor H,Abrams P,Brookes ST,Cotterill N,Noble SM,Page T,Swami KS,Lane JA,Hashim H

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with increasing prevalence. It can manifest with many different clinical phenotypes; however, in its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi...

journal_title：Trials

authors： Yun Y,Ko Y,Ahn JH,Jang BH,Kim K,Ko SG,Choi I

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:Mobile health (mHealth) presents one of the potential solutions to maximize health worker impact and efficiency in an effort to reach the Sustainable Development Goals 3.1 and 3.2, particularly in sub-Saharan African countries. Poor-quality clinical decision-making is known to be associated with poor pregnan...

journal_title：Trials

authors： Amoakoh HB,Klipstein-Grobusch K,Amoakoh-Coleman M,Agyepong IA,Kayode GA,Sarpong C,Grobbee DE,Ansah EK

更新日期：2017-04-04 00:00:00

abstract：BACKGROUND:To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils-Listerine Zero (LZ)-and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo ...

journal_title：Trials

authors： Marchetti E,Tecco S,Caterini E,Casalena F,Quinzi V,Mattei A,Marzo G

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) is commonly associated with cognitive and functional impairments even during remission periods, and although a growing number of studies have demonstrated the benefits of psychotherapy as an add-on to pharmacological treatment, its effectiveness appears to be less compelling in severe p...

journal_title：Trials

authors： Gomes BC,Rocca CC,Belizario GO,Lafer B

更新日期：2017-03-28 00:00:00

abstract：BACKGROUND:Resistant hypertension is defined as an uncontrolled blood pressure despite treatment at best-tolerated doses with at least three antihypertensive agents including a diuretic. It is an emerging public health problem. At present clinical trial data on management of resistant hypertension is limited. Managemen...

journal_title：Trials

authors： Constantine GR,Ranasinghe P,Weeratunga P,Weeraratne C,Galappatthy P,Rajapakse S,Senarath U,Katulanda P

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Children in low and middle-income countries (LMICs) are at risk for problems in their cognitive, social and behavioural development. Factors such as a lack of cognitive stimulation, harsh parenting practices, and severe and persistent aggression in early childhood are central to the genesis of these problems...

journal_title：Trials

authors： Dowdall N,Cooper PJ,Tomlinson M,Skeen S,Gardner F,Murray L

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:Acupressure therapy may be potentially beneficial in improving postoperative symptoms like postoperative nausea and vomiting (PONV), pain and sleep disorder and improving postoperative quality of recovery. The primary aim of this study is to investigate the efficacy of acupressure therapy on postoperative pa...

journal_title：Trials

authors： Noll E,Shodhan S,Madariaga MC,Page CR,Santangelo D,Guo X,Al Bizri E,Pryor AD,Romeiser J,Bennett-Guerrero E

更新日期：2017-03-07 00:00:00

abstract：BACKGROUND:Radiation therapy (RT) of bone metastases provides an important treatment approach in palliative care treatment concepts. As a consequence of treatment, the extent of radiation-induced toxicity is a crucial feature with consequences to a patient's quality of life. In this context this study aims at reducing ...

journal_title：Trials

authors： Meyerhof E,Sprave T,Welte SE,Nicolay NH,Förster R,Bostel T,Bruckner T,Schlampp I,Debus J,Rief H

更新日期：2017-03-03 00:00:00

abstract：BACKGROUND:Liver failure patients have traditionally been empirically transfused prior to invasive procedures. Blood transfusion is associated with immunologic and nonimmunologic reactions, increased risk of adverse outcomes and high costs. Scientific evidence supporting empirical transfusion is lacking, and the best a...

journal_title：Trials

authors： Rocha LL,Pessoa CM,Neto AS,do Prado RR,Silva E,de Almeida MD,Correa TD,POCKET Trial Investigators.

更新日期：2017-02-27 00:00:00

abstract：:Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise the use of data and permit the exploration of additional hypotheses. On the other hand, the quality of secondary analyses cannot always be ascertained, and it may be unfair to investigators who ...

journal_title：Trials

authors： Mbuagbaw L,Foster G,Cheng J,Thabane L

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Linezolid, an oxazolidinone, substantially improves treatment outcomes of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We started a trial to test whether the use of linezolid instead of ethambutol could increase the rate of sputum culture conversion as of 8 weeks of treatment...

journal_title：Trials

authors： Lee JY,Kim DK,Lee JK,Yoon HI,Jeong I,Heo E,Park YS,Lee JH,Park SS,Lee SM,Lee CH,Lee J,Choi SM,Park JS,Joh JS,Cho YJ,Lee YJ,Kim SJ,Hwang YR,Kim H,Ki J,Choi H,Han J,Ahn H,Hahn S,Yim JJ

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Chest tube insertion is a standard intervention for management of various injuries of the thorax. Quick and accurate execution facilitates efficient therapy without further complications. Here, we propose a new training concept comprised of e-learning elements as well as continuous rating using an objective ...

journal_title：Trials

authors： Friedrich M,Bergdolt C,Haubruck P,Bruckner T,Kowalewski KF,Müller-Stich BP,Tanner MC,Nickel F

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:The introduction of anti-tumor necrosis factor medications has revolutionized the treatment of psoriasis with achievement of treatment goals (Psoriasis Area and Severity Index score 75, remission) that are not usually met with conventional systemics. Nevertheless, some patients continue to experience persist...

journal_title：Trials

authors： Busard CI,Menting SP,van Bezooijen JS,van den Reek JM,Hutten BA,Prens EP,de Jong EM,van Doorn MB,Spuls PI

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:Aortic valve replacement is one of the most common cardiac surgical procedures performed worldwide. Conventional aortic valve replacement surgery is performed via a median sternotomy; the sternum is divided completely from the sternal notch to the xiphisternum. Minimally invasive aortic valve replacement, us...

journal_title：Trials

authors： Akowuah E,Goodwin AT,Owens WA,Hancock HC,Maier R,Kasim A,Mellor A,Khan K,Murphy G,Mason J

更新日期：2017-01-28 00:00:00

abstract：BACKGROUND:Approximately 50% of heart failure patients are readmitted to hospital within 6 months, owing to deterioration of their condition. Thus, symptomatic treatment of heart failure requires significant improvement. The aim of this study is to compare the effects of torasemide and furosemide on biochemical paramet...

journal_title：Trials

authors： Balsam P,Ozierański K,Tymińska A,Główczyńska R,Peller M,Fojt A,Cacko A,Sieradzki B,Bakuła E,Markulis M,Kowalik R,Huczek Z,Filipiak KJ,Opolski G,Grabowski M

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the ef...

journal_title：Trials

authors： Demant MN,Jensen RG,Jakobsen JC,Gluud C,Homøe P

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:Despite recent advances in the medical and surgical fields, complications such as infection, pneumonia, or brain swelling may occur after a craniotomy. In some patients, perioperative antibiotic prophylaxis causes adverse effects such as itching, rash, or digestive conditions. Certain patients still develop ...

journal_title：Trials

authors： Cho SY,Yang SB,Shin HS,Lee SH,Koh JS,Kwon S,Jung WS,Moon SK,Park JM,Ko CN,Park SU

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Postoperative knee swelling is common and impairs early postoperative function following total knee arthroplasty. It was hypothesised that the use of a short-stretch, inelastic compression bandage would reduce knee swelling and improve pain and early function. The aim of this study was to provide preliminary...

journal_title：Trials

authors： Brock TM,Sprowson AP,Muller S,Reed MR

更新日期：2017-01-09 00:00:00

abstract：BACKGROUND:People with serious mental illness (SMI) (psychosis, bipolar disorder and major depressive disorder) experience a considerable risk of premature mortality because of cardiovascular disease. Recent research has demonstrated that this population spends almost 13 h per day being sedentary. Sedentary behaviour i...

journal_title：Trials

authors： Williams J,Stubbs B,Gaughran F,Craig T

更新日期：2016-12-12 00:00:00